Lerchen, Hans-Georg: search on Z-Library

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1

Antibody-prodrug conjugates with KSP inhibitors and legumain mediated metabolite formation

Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Berndt, Sandra, Sommer, Anette, Dietz, Lisa, Rebstock, Anne-Sophie, Johannes, Sarah, Marx, Leo, Jörißen, Hannah, Mahlert, Christoph, Greven, Simone

Journal:

Chemistry - A European Journal

Year:

2019

File:

PDF, 1.29 MB

2019

2

Synthesis of Muropeptide Conjugates of 2,3-Dideoxy-β-D-manno-2-octulosonic Acid

Dr. Hans-Georg Lerchen, Dr. Hein-Peter Kroll

Journal:

Angewandte Chemie International Edition

Year:

1991

Language:

english

File:

PDF, 310 KB

english, 1991

3

Antibody-Drug Conjugates with Pyrrole-Based KSP Inhibitors as the Payload Class

Lerchen, Hans-Georg, Wittrock, Sven, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne-Sophie, Johannes, Sarah, Cancho-Grande, Yolanda, Mahlert, Christoph, Greven

Journal:

Angewandte Chemie International Edition

Year:

2018

File:

PDF, 1.27 MB

2018

4

Synthetic studies towards bottromycin

Ackermann, Stefanie, Lerchen, Hans-Georg, Häbich, Dieter, Ullrich, Angelika, Kazmaier, Uli

Journal:

Beilstein Journal of Organic Chemistry

Year:

2012

Language:

english

File:

PDF, 317 KB

english, 2012

5

Synthesis of 20-O-linked 20(S)-Camptothecin Glycoconjugates: Impact of the Side Chain of the Ester-linked Amino Acid on Epimerization During the Acylation Reaction and on Hydrolytic Stability of the Final Glycoconjugates

Hans-Georg Lerchen, Karsten von dem Bruch

Journal:

Advanced Synthesis & Catalysis

Year:

2000

Language:

english

File:

PDF, 63 KB

english, 2000

6

Antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

Lerchen, Hans-Georg, Wittrock, Sven, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne-Sophie, Johannes, Sarah, Cancho-Grande, Yolanda, Mahlert, Christoph, Greven

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

7

Neutrophil Elastase Promotes Linker Cleavage and Paclitaxel Release from an Integrin-Targeted Conjugate

Raposo Moreira Dias, André, Pina, Arianna, Dean, Amelia, Lerchen, Hans-Georg, Caruso, Michele, Gasparri, Fabio, Fraietta, Ivan, Troiani, Sonia, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Dal Co

Journal:

Chemistry - A European Journal

Year:

2018

Language:

english

File:

PDF, 1.33 MB

english, 2018

8

Synthese des all-L-konfigurierten Cyclohexadepsipeptids cyclo-[L-Val-L-Lac]3 nach der Peoc/Säurechlorid-Methode

Prof. Dr. Horst Kunz, Hans-Georg Lerchen

Journal:

Angewandte Chemie

Year:

1984

Language:

german

File:

PDF, 237 KB

german, 1984

9

Arginine–pyrimidine conjugates with therapeutic and prophylactic activity in lethal bacterial infections

Dieter Haebich, Hein-Peter Kroll, Hans-Georg Lerchen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 180 KB

english, 2009

10

Synthesis of Cholecystokinin-Related Peptides and Their Biological Properties

WÜNSCH, Erich, MORODER, Luis, LERCHEN, Hans-Georg, CHRISTOPHE, Jean, SVOBODA, Michal

Journal:

Biological Chemistry Hoppe-Seyler

Year:

1989

Language:

english

File:

PDF, 1.05 MB

english, 1989

11

Lectin-Mediated Drug Targeting: Discrimination of Carbohydrate-Mediated Cellular Uptake between Tumor and Liver Cells with Neoglycoconjugates Carrying Fucose Epitopes Regioselectively Modified in the 3-Position

Hans-Georg Lerchen, Joerg Baumgarten, Norbert Piel, Victoria Kolb-Bachofen

Journal:

Angewandte Chemie International Edition

Year:

1999

Language:

english

File:

PDF, 121 KB

english, 1999

12

Neladenoson Bialanate Hydrochloride: A Prodrug of a Partial Adenosine A 1 Receptor Agonist for the Chronic Treatment of Heart Diseases

Meibom, Daniel, Albrecht-Küpper, Barbara, Diedrichs, Nicole, Hübsch, Walter, Kast, Raimund, Krämer, Thomas, Krenz, Ursula, Lerchen, Hans-Georg, Mittendorf, Joachim, Nell, Peter G., Süssmeier, Frank, V

Journal:

Year:

2017

Language:

english

File:

PDF, 852 KB

english, 2017

13

Preclinical Antitumor Efficacy of BAY 1129980—a Novel Auristatin-Based Anti-C4.4A (LYPD3) Antibody–Drug Conjugate for the Treatment of Non–Small Cell Lung Cancer

Willuda, Jörg, Linden, Lars, Lerchen, Hans-Georg, Kopitz, Charlotte, Stelte-Ludwig, Beatrix, Pena, Carol, Lange, Claudia, Golfier, Sven, Kneip, Christoph, Carrigan, Patricia E., Mclean, Kirk, Schuhmac

Journal:

Molecular Cancer Therapeutics

Year:

2017

Language:

english

File:

PDF, 10.14 MB

english, 2017

14

Design and Optimization of 20-O-Linked Camptothecin Glycoconjugates as Anticancer Agents

Lerchen, Hans-Georg, Baumgarten, Joerg, von dem Bruch, Karsten, Lehmann, Thomas E., Sperzel, Michael, Kempka, Grazyna, Fiebig, Heinz-Herbert

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 207 KB

english, 2001

15

Stereocontrolled synthesis of D-α-hydroxy carboxylic acid from L-amino acids

Horst Kunz, Hans-Georg Lerchen

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 184 KB

english, 1987

16

IL3RA-Targeting AntibodyâDrug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

Kirchhoff, Dennis, Stelte-Ludwig, Beatrix, Lerchen, Hans-Georg, Wengner, Antje Margret, Ahsen, Oliver von, Buchmann, Pascale, MÃ¤rsch, Stephan, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, Erkelen

Journal:

Year:

2020

File:

PDF, 1.60 MB

2020

17

Antibody-drug conjugates with pyrrole-based KSP inhibitors as novel payload class

Lerchen, Hans-Georg, Wittrock, Sven, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Griebenow, Nils, Rebstock, Anne-Sophie, Johannes, Sarah, Cancho-Grande, Yolanda, Mahlert, Christoph, Greven

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.14 MB

english, 2018

18

Lectin-vermitteltes Drug-Targeting: Diskriminierung zwischen der Kohlenhydrat-vermittelten Aufnahme von Neoglycokonjugaten, die in 3-Position modifizierte Fucose-Epitope tragen, in Tumor- oder Leberzellen

Hans-Georg Lerchen, Joerg Baumgarten, Norbert Piel, Victoria Kolb-Bachofen

Journal:

Angewandte Chemie

Year:

1999

Language:

german

File:

PDF, 136 KB

german, 1999

19

Tailored linker chemistries for the efficient and selective activation of ADCs with KSPi payloads

Lerchen, Hans-Georg, Stelte-Ludwig, Beatrix, Sommer, Anette, Berndt, Sandra, Rebstock, Anne-Sophie, Johannes, Sarah, Mahlert, Christoph, Greven, Simone, Dietz, Lisa, JÃ¶riÃen, Hannah

Journal:

Bioconjugate Chemistry

Year:

2020

File:

PDF, 289 KB

2020

20

A Selective Carborane-Functionalized Gastrin-Releasing Peptide Receptor Agonist as Boron Delivery Agent for Boron Neutron Capture Therapy

Hoppenz, Paul, Els-Heindl, Sylvia, Kellert, Martin, Kuhnert, Robert, Saretz, Stefan, Lerchen, Hans-Georg, Köbberling, Johannes, Riedl, Bernd, Hey-Hawkins, Evamarie, Beck-Sickinger, Annette G.

Journal:

Journal of Organic Chemistry

Year:

2019

File:

PDF, 844 KB

2019

21

Stereoselektive synthese von D-α-hydroxycarbonsäuren bzw. D-α-hydroxycarbonsäuren enthaltenden depsipeptiden aus L-aminosäuren

Hans-Georg Lerchen, Horst Kunz

Journal:

Tetrahedron Letters

Year:

1985

File:

PDF, 205 KB

1985

22

Synthesis of the all-L-Configurated Cyclohexadepsipeptide cyclo-[L-Val-L-Lac]3 by the Peoc/Acid Chloride Method

Prof. Dr. Horst Kunz, Dipl.-Chem. Hans-Georg Lerchen

Journal:

Angewandte Chemie International Edition

Year:

1984

Language:

english

File:

PDF, 218 KB

english, 1984

23

Synthese von Zellwandpeptidkonjugaten der 2,3-Didesoxy-β-D-manno-2-octulosonsäure

Dr. Hans-Georg Lerchen, Dr. Hein-Peter Kroll

Journal:

Angewandte Chemie

Year:

1991

Language:

german

File:

PDF, 214 KB

german, 1991

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